Remdesivir, HCQ have no antiviral effects: WHO study

Neither Remdesivir, nor hydroxychloroquine (HCQ) helps in recovery of patients hospitalised due to Covid-19, according to a new study conducted by the World Health Organization (WHO).

The study, led by researchers from the Oslo University Hospital in Norway, found that lack of antiviral effect with Remdesivir and HCQ remained consistent despite patient age, symptom duration, degree of viral load, and presence of antibodies against SARS-CoV-2.

For the study, the team randomly assigned 181 hospitalised patients in 23 hospitals in Norway to receive Remdesivir, HCQ, or standard of care to evaluate the effects of Remdesivir and HCQ on all-cause, in-hospital mortality; the degree of respiratory failure and inflammation; and viral clearance in the oropharynx.

The researchers found no significant differences between treatment groups in mortality during hospitalization. Remdesivir and HCQ did not affect the degree of respiratory failure or inflammation. The findings are published in Annals of Internal Medicine.

Based on their findings, the researchers question the antiviral potential of remdesivir and HCQ.

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